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目的研究尘肺患者肝功能各项指标的改变特征。方法 698例尘肺患者为患者组,52例健康检查者为对照组。采用Glamour-1600型全自动生化分析仪。测定丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和γ-谷氨酰转移酶(γ-GT)活力。结果不同年龄组和不同性别的尘肺患者组AST和γ-GT活力均显著高于对照组(P<0.01)。40～49和50～59岁组男性ALT活力高于对照组(P<0.01)。不同年龄患者组中,男、女患者间各项指标水平存在不同程度的差异。结论尘肺患者ALT、AST和γ-GT活力显著增高,尤其AST和γ-GT活力能较为敏感地反映患者的组织损伤。
Objective To study the changing characteristics of various indexes of liver function in patients with pneumoconiosis. Methods 698 cases of pneumoconiosis patients for the patient group, 52 cases of health check-up for the control group. Using Glamor-1600 automatic biochemical analyzer. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (γ-GT) activity were measured. Results The activities of AST and γ-GT in patients with pneumoconiosis of different age groups and different genders were significantly higher than those of the control group (P <0.01). The ALT activity of male in 40-49 and 50-59 years old group was higher than that in control group (P <0.01). Different age groups of patients, male and female patients with different levels of the indicators there are different degrees of difference. Conclusion The levels of ALT, AST and γ-GT were significantly increased in patients with pneumoconiosis. In particular, the activity of AST and γ-GT were more sensitive to the tissue damage in patients with pneumoconiosis.