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目的:通过研究骨质疏松大鼠的模型材料力学的指标在不同强度脉冲电磁场作用下的变化,探讨对骨质疏松的脉冲电磁场治疗的最适强度。方法:将50只雌性3月龄SD大鼠按随机分组的原则分为5组:0.77m T组、3.82m T组、9.87m T组、假手术对照组、模型对照组,每组10只。0.77m T组、3.82m T组和9.87m T组大鼠每天在频率为8Hz,磁场感应分别为0.77m T、3.82m T和9.87m T的磁场环境中干预40min,共30d。假手术对照组和模型对照组不干预。结果:3.82m T组各项材料力学指标与0.77m T、9.82m T组和模型对照组比较,差异有统计学意义(P<0.05)。结论:磁感应强度为3.82m T的PEMFs能明显改善骨质疏松大鼠股骨材料力学特性。
OBJECTIVE: To investigate the optimal strength of pulsed electromagnetic field therapy for osteoporosis by studying the changes of model material mechanics of osteoporosis rats under the action of pulsed electromagnetic fields of different intensities. Methods: 50 female 3-month-old SD rats were randomly divided into five groups: 0.77m T group, 3.82m T group, 9.87m T group, sham operation control group and model control group, 10 rats in each group . The rats in 0.77m T group, 3.82m T group and 9.87m T group were exposed to magnetic field environment with frequency of 8Hz and magnetic field induction of 0.77m T, 3.82m T and 9.87m T for 40min every day for 30 days. Sham operation control group and model control group did not intervene. Results: The mechanical indexes of 3.82m T group were significantly different from those of 0.77m T, 9.82m T group and model control group (P <0.05). CONCLUSION: PEMFs with magnetic induction of 3.82 mT can significantly improve the mechanical properties of femur in osteoporotic rats.