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目的循证评价全球儿童基本药物目录(Essential Medicine List for Children,EMLc)构建方法,为建立我国EMLc提供方法学参考。方法计算机检索Pro Quest、Science Direct、Springer Link、MEDLINE数据库、WHO官方网站和67个国家卫生部与药品监管部门网站,获取基本药物目录(Essential Medicine List,EML)遴选方法学文献,进行描述性分析。结果最终纳入文献14篇,包括EMLc遴选方法 6篇,成人EML遴选方法 8篇。WHO建立了独立的EMLc遴选机构,WHO与印度EMLc遴选工作均由儿科专家参与。目前全球尚无针对EMLc的遴选标准、流程,WHO、印度与南非的EMLc均参考WHO EML遴选标准和流程,尚未检索到印度与南非EMLc遴选流程相关文献。WHO、南非EMLc已有更新时间、周期和流程,其中WHO EMLc每2年定期更新,频率高,流程严谨,印度EMLc尚未更新。结论建议我国儿童基本药物遴选参考WHO儿童健康工作小组(Child HealtThWorking Group,CHWG)即WHO EMLc遴选机构的工作模式,建立中国EMLc遴选工作组,强调儿科专家与循证方法学专家的参与;建议参考WHO EML遴选标准,根据我国儿童疾病负担、药品可及性、医疗保险水平等国情,循证制定我国EMLc的遴选标准;与成人目录同步更新目录。
Objective To evaluate the construction method of Essential Medicine List for Children (EMLc) based on evidence and to provide a methodology reference for the establishment of EMLc in China. Methods We searched the website of Pro Quest, Science Direct, Springer Link, MEDLINE, WHO website and 67 websites of Ministry of Health and Drug Regulatory Affairs to obtain the Essential Medicine List (EML) selection methodological literature for descriptive analysis . The final results included 14 articles, including 6 EMLc selection methods and 8 adult EML selection methods. WHO established an independent EMLc selection agency, WHO and India EMLc selection by pediatric experts involved. Currently, there is no selection criteria for EMLc in the world. The EMLc of WHO, India, South Africa and South Africa refer to the WHO EML selection criteria and procedures. No relevant literature has been retrieved on the EMLc selection process in India and South Africa. WHO, South Africa EMLc has been updated time, cycle and process, including WHO EMLc every 2 years regularly updated, high frequency, rigorous process, India EMLc has not been updated. Conclusions It is suggested that the selection of children’s essential medicines in China refer to the working model of the WHO Healing Working Group (CHWG), the WHO EMLc selection body, and establish the EMLc Selection Working Group in China, emphasizing the participation of pediatric experts and evidence-based methodologists; WHO EML selection criteria, according to China’s burden of disease, drug accessibility, the level of medical insurance and other national conditions, evidence-based development of China’s EMLc selection criteria; and adult directory synchronization update directory.