论文部分内容阅读
目的 探讨烟雾病与颅内动脉瘤之间的关系。方法 用颈局部注射马血清方法建立烟雾病合并颅内动脉瘤的实验动物模型。结果 颈动脉受免疫复合物损伤后 ,内弹力层变性、迂曲、断裂 ,中膜平滑肌细胞沿弹力纤维断裂处向内膜伸入增生 ,致管腔狭窄或闭塞。脑组织长期缺血 ,小血管代偿性增生形成异网 ,同时 ,颅内动脉壁受免疫复合物损伤后 ,局部弹力纤维变性、断裂 ,在侧支血流冲击下向外突出 ,形成动脉瘤。本实验 10只动物中 4只产生 5个动脉瘤 (X线示颈内动脉区囊状动脉瘤 1个 ,镜下见 3只动物有 4个微小动脉瘤 )。结论 免疫损伤不但可以引起烟雾病而且可以引起动脉瘤。
Objective To explore the relationship between moyamoya disease and intracranial aneurysm. Methods Experimental animal models of moyamoya disease with intracranial aneurysm were established by local injection of horse serum into the neck. Results The carotid artery was damaged by the immune complex. The inner elastic layer degenerated, tortured and ruptured. The smooth muscle cells of the tunica media extended into the intima along the rupture of the elastic fibers and caused stenosis or occlusion of the lumen. Long-term ischemic brain tissue, compensatory proliferation of small blood vessels to form the same network, while intracranial arterial wall injury by the immune complex, local elastic fibers degeneration, rupture, collateral blood flow in the impact of protruding outward, the formation of aneurysms . Four of 10 animals in this experiment produced 5 aneurysms (X-ray showed 1 intracavitary aneurysm in the internal carotid artery and 3 microscopic aneurysms in 3 animals). Conclusion Immune damage can not only cause moyamoya disease but also cause aneurysm.