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目的:观察促排卵方对PCOS性不孕大鼠卵巢局部的影响,探讨其对PCOS性不孕大鼠卵巢的干预环节和作用机制。方法:选用DHEA制作PCOS性不孕大鼠模型。观察大鼠卵巢外观、病理学组织形态、卵巢重量指数及卵巢最大横截面积的变化。结果:促排卵方能改善大鼠卵巢外观和病理学组织形态,明显升高大鼠卵巢重量指数,降低大鼠卵巢最大横截面积,与模型组的比较具有非常显著性差异(P<0.01);促排卵方用量达高剂量时,疗效值与克罗米芬组的比较,具有显著性差异(P<0.05),并接近空白对照组。结论:促排卵方能改善PCOS性不孕大鼠卵巢形态及病理学组织形态,升高大鼠卵巢重量指数、降低大鼠卵巢最大横截面积,可以促进卵泡的生长、发育,成熟,从而达到促排卵的目的。
OBJECTIVE: To observe the effect of ovulation-precipitating prescription on ovaries of PCOS infertility rats, and to explore its interventional mechanism and action mechanism on ovaries of PCOS infertility rats. Methods: DHEA was used to make PCOS infertility rat model. Observed changes in the appearance of the ovary, pathological histology, ovarian weight index, and ovary maximum cross-sectional area. RESULTS: Stimulating ovulation could improve the appearance and pathological morphology of rat ovary, significantly increase the weight index of rat ovary, and decrease the maximum cross-sectional area of ovary of rats, which was significantly different from the model group (P<0.01). When the dosage of ovulation prescription was high, the curative effect value was significantly different from that of clomiphene group (P<0.05), and it was close to the blank control group. Conclusion: Ovulation-promoting can improve ovarian morphology and pathological morphology of PCOS infertility rats. Elevating rat ovarian weight index and decreasing the maximum cross-sectional area of rat ovary can promote the growth, development and maturation of follicles, thus achieving The purpose of ovulation.