论文部分内容阅读
检测８７例脑血管病（ＣＶＤ）患者血清超氧化物歧化酶（ＳＯＤ）同工酶活性、丙二醛（ＭＤＡ）含量，并对其中３４例患者红细胞内ＳＯＤ（ＲＢＣ－ＳＯＤ）活性进行检测，对其相互间的关系进行了探讨。结果表明，血清总ＳＯＤ（Ｔ－ＳＯＤ）、Ｍｎ－ＳＯＤ活性和ＭＤＡ含量明显高于正常对照组，ＣｕＺｎ－ＳＯＤ活性无变化或显著降低及ＲＢＣ－ＳＯＤ活性均明显低于对照组。其相关性表现为Ｔ－ＳＯＤ及Ｍｎ－ＳＯＤ与ＭＤＡ的改变呈显著正相关（ｒ＝０．９３２３，Ｐ＜０．００１；ｒ＝０．９２１５，Ｐ＜０．００１），ＣｕＺｎ－ＳＯＤ与ＭＤＡ的改变呈显著负相关（ｒ＝－０．８８６１，Ｐ＜０．００１）。提示这些变化可作为判断脑血管病变发展和严重程度的重要参数。
Serum superoxide dismutase (SOD) isoenzymes and malondialdehyde (MDA) were detected in 87 patients with cerebrovascular disease (CVD). The activity of erythrocyte SOD (RBC-SOD) in 34 patients was detected, The relationship between them was discussed. The results showed that the activities of serum total superoxide dismutase (SOD), Mn-SOD and MDA in serum were significantly higher than those in normal control group. There was no change or significant decrease in CuZn-SOD activity and RBC-SOD activity in control group. The correlation between T-SOD, Mn-SOD and MDA was positively correlated (r = 0.9323, P <0.001; r = 0.9215, P <0.001) There was a significant negative correlation between changes of MDA (r = -0.8861, P <0.001). Suggesting that these changes can be used as an important parameter to judge the development and severity of cerebrovascular disease.