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人类乙型肝炎病毒(HBV)、土拨鼠肝炎病毒(WHV)、地松鼠肝炎病毒(GSHV)和鸭肝炎病毒(DHBV)同属嗜肝DNA病毒族,并具有独特的超微结构和生物学特征。嗜肝DNA病毒的分子生物学是研究病毒基因表达与复制,即病毒DNA、RNA和蛋白质的结构与功能。近年来该领域的研究进展很快,本文拟就近期,尤其今年元月召开的上海国际肝癌与肝炎会上有关的报道综述如下。嗜肝DNA病毒的基因组结构如图1,嗜肝DNA病毒基因组属环状DNA分子,部分区域呈单链结构,病毒DNA分子由一约3,000～3,300个碱基对(bp)
Human hepatitis B virus (HBV), woodchuck hepatitis virus (WHV), ground squirrel hepatitis virus (GSHV) and duck hepatitis virus (DHBV) belong to the group of hepadnavirus and have unique ultrastructural and biological characteristics . The molecular biology of hepadnavirus is to study the structure and function of viral gene expression and replication, ie, viral DNA, RNA and proteins. In recent years, the research progress in this area is very fast. This article is intended to summarize the recent reports of Shanghai International Hepatitis and Hypertension Conference held recently in January this year. Hepadnavirus genomic structure shown in Figure 1, hepadnavirus genomic circular DNA molecules, part of the region was single-stranded structure, the viral DNA molecules from about 3,000 to 3,300 base pairs (bp)