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目的 观察硝卡芥联合白细胞介素 -II治疗恶性胸腔积液的疗效及不良反应。方法 对 2 8例恶性胸腔积液患者采用常规胸腔穿刺抽液术 ,尽量抽尽胸水后 ,于胸腔内注入硝卡芥 80mg +生理盐水 2 0ml,然后注入白细胞介素 -II 10 0万 μ +生理盐水 2 0ml,每周 1次 ,4周后评价疗效。 结果 2 8例患者CR4例(14 .3% ) ,PR14例 (5 0 % ) ,总有效率 (CR +PR) 6 4 .3%。主要不良反应为胸痛 8例 (2 8.6 % ) ,低热 7例(2 5 % )。结论 胸腔内注入硝卡芥联合白细胞介素 -II能有效地控制恶性胸腔积液 ,临床应用方便、经济 ,毒副反应小 ,具有临床应用价值
Objective To observe the curative effect and adverse reactions of nitidine caffate combined with interleukin-II in the treatment of malignant pleural effusion. Methods Twenty-eight patients with malignant pleural effusion underwent routine thoracentesis and pleural effusion. After pleural effusion was aspirated, nitrendipine 80mg + saline 20ml was infused into the thoracic cavity, and then injected with 10 million μL of interleukin-II Physiological saline 2 0ml, once a week, 4 weeks after the evaluation of efficacy. Results 28 patients were CR4 cases (14.3%), PR14 cases (50%), the total effective rate (CR + PR) was 6.4%. The main adverse reactions were chest pain in 8 cases (22.6%) and fever in 7 cases (25%). Conclusions Thoracic injection of nitidine catechin combined with interleukin-II can effectively control malignant pleural effusion. It has the advantages of convenient clinical application, low cost, little side effect and clinical value