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动态监测２０例大手术创伤患儿术后血管升压素异常分泌综合征（ＳＩＡＤＨ）的发生情况。采用放射免疫法分别于术前、术后ｌｈ、８ｈ和４８ｈ测定血浆血管升压素（ＡＤＨ）、心房钠尿肽（ＡＮＰ）、肾素（ＰＲＡ）、血管紧张素ＩＩ（ＡＩＩ）和醛固酮（ＡＬＤ），以探讨术后ＳＩＡＤＨ的内分泌调节机制。结果：８例于术后发生ＳＩＡＤＨ，其术后１ｈ血浆ＡＤＨ、ＡＮＰ、ＰＲＡ、ＡＩＩ和ＡＬＤ均升高；术后８ｈＡＤＨ和ＡＮＰ继续升至峰值，ＰＲＡ、ＡＩＩ和ＡＬＤ则明显下降，低于术前水平。术后４８ｈ除ＡＬＤ外均逐渐恢复。１２例术后未发生ＳＩＡＤＨ者，上述激素水平无显著变化。提示术后８ｈ内应限制输入液量。
Dynamic monitoring of 20 cases of surgical trauma children postoperative abnormalities of vasopressin syndrome (SIADH) incidence. The levels of plasma vasopressin (ADH), atrial natriuretic peptide (ANP), renin (PRA), angiotensin II (AII) and aldosterone (ALD) were measured by radioimmunoassay before operation, ALD) to explore the postoperative SIADH endocrine regulation mechanism. Results: After operation, SIADH occurred in 8 cases, and the levels of ADH, ANP, PRA, AII and ALD in plasma increased at 1 hour after operation. After 8 hours, the levels ofADH and ANP continued to rise, while the levels of PRA, AII and ALD decreased significantly Before the level. 48h after operation except ALD were gradually recovered. 12 cases of SIADH who did not occur after the above hormone levels did not change significantly. Tips 8h after surgery should limit the amount of input fluid.