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目的探讨注射人绒毛膜促性腺激素(HCG)当天孕激素水平及雌孕激素比值对体外受精-胚胎移植(IVF-ET)妊娠率的影响。方法2006年5月至2007年3月在贵阳市妇幼保健院生殖中心就诊279例不孕症患者300个周期进行IVF-ET治疗,在注射HCG当天测定雌二醇(E2)、孕酮(P)。按注射HCG日所测血清P水平分为3组:第1组P≤2.86nmol/L131周期;第2组2.86nmol/L9.54nmol/L77周期。按P/E2比值分为2组:注射HCG日P/E2<1组219例,P/E2≥1组81例。结果按P水平分组,第3组妊娠率(27.2%)明显低于其他2组(第1组52.6%,第2组45.6%),P<0.05。P/E2<1组妊娠率(49.8%)高于P/E2≥1组(28.4%),P<0.05。结论在IVF-ET治疗中注射HCG当天血清P水平及P/E2比值影响妊娠结局,是预测IVF-ET妊娠率的较好指标。
Objective To investigate the effect of progesterone level and the ratio of estrogen, progesterone and progesterone on the pregnancy rate of in vitro fertilization-embryo transfer (IVF-ET) in human chorionic gonadotropin (HCG) injection. Methods From May 2006 to March 2007, 279 infertility patients were treated with IVF-ET for 300 cycles in the Reproductive Center of Gynecology and MCH in Guiyang. Serum estradiol (E2), progesterone (P ). The serum P level measured on the day of HCG injection was divided into 3 groups: group 1 P≤2.86nmol / L131 cycle; group 2 2.86nmol / L 9.54nmol / L77 cycle. According to the ratio of P / E2, the mice were divided into 2 groups: 219 cases were injected P / E2 on HCG day, 81 cases were on P / E2≥1. The results were grouped according to the P level. The pregnancy rate in group 3 (27.2%) was significantly lower than that in the other 2 groups (52.6% in group 1 and 45.6% in group 2), P <0.05. Pregnancy rate (49.8%) in P / E2 <1 group was higher than that in P / E2≥1 group (28.4%), P <0.05. Conclusions The serum P level and P / E2 ratio on the day of HCG injection in IVF-ET treatment affect the pregnancy outcome, which is a good indicator to predict the pregnancy rate of IVF-ET.