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[目的]观察枸橼酸莫沙必利分散片与尼莫地平联用治疗老年人糖尿病胃轻瘫(DGP)的临床疗效。[方法]选择2008年6月～2010年6月某院收治的96例DGP老年患者,按随机数字表法分为观察组和对照组各48例。对照组给予枸橼酸莫沙必利分散片治疗,观察组在此基础上加用尼莫地平。[结果]两组治疗后GET1均明显缩短(P/2﹤0.05),且相比对照组,观察组缩短更为显著(P﹤0.05);观察组总有效率(93.7%,45/48)显著高于对照组(75.0%,36/48)(P﹤0.05);观察组和对照组不良反应发生率分别为4.2%(2/48)和6.3%(3/48),差异无统计学意义(P﹥0.05)。[结论]枸橼酸莫沙必利分散片与尼莫地平联用治疗老年人糖尿病胃轻瘫可发挥协同作用,显著提高疗效,不良反应少,值得临床推广应用。
[Objective] To observe the clinical efficacy of mosapride citrate dispersible tablets combined with nimodipine in the treatment of diabetic gastroparesis (DGP) in the elderly. [Methods] Ninety-six elderly patients with DGP admitted to our hospital from June 2008 to June 2010 were divided into observation group and control group according to the random number table method, 48 cases each. The control group was treated with mosapride citrate dispersible tablets. The observation group was given nimodipine on this basis. [Results] The GET1 in both groups was significantly shortened (P <0.05). Compared with the control group, the shortening of the observation group was more significant (P <0.05). The total effective rate (93.7%, 45/48) (P <0.05). The incidence of adverse reactions in the observation group and the control group were 4.2% (2/48) and 6.3% (3/48) respectively, with no significant difference between the two groups Significance (P> 0.05). [Conclusion] Combination of mosapride citrate dispersible tablets and nimodipine in the treatment of elderly diabetic gastroparesis can play a synergistic effect, significantly improve the curative effect and less adverse reactions, which is worthy of clinical application.