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妊娠期急性脂肪肝(acute fatty liver of pregnancy,AFLP),又称妊娠特发性脂肪肝,是妊娠晚期发生的一种罕见的致死性疾病,发病率为1/6692～1/13328,临床罕见,起病急、进展快、预后凶险,母婴病死率分别高达75%、85%,并发多脏器功能不全综合征(MOF)后病死率高达80%～90%[1]。我科于2012年12月收治1例妊娠急性重症脂肪肝并发多脏器功能障碍后死亡病例,现将临床资料进行分析,以有助于产科医师对AFLP的早期辨别、诊断及治疗。
Acute fatty liver of pregnancy (acute fatty liver of pregnancy, AFLP), also known as pregnancy idiopathic fatty liver, is a rare fatal disease occurred in late pregnancy, the incidence rate of 1/6692 ~ 1/13328, clinically rare , Acute onset, rapid progression, dangerous prognosis, maternal and child mortality rates were as high as 75%, 85%, complicated with multiple organ dysfunction syndrome (MOF) mortality after as high as 80% to 90% [1]. Our department in December 2012 admitted to a case of acute fatty liver of pregnancy complicated by multiple organ dysfunction death cases, the clinical data are now analyzed to help obstetric physicians AFLP early identification, diagnosis and treatment.