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目的 寻找硒拮抗氟毒作用的最佳作用浓度及氟中毒的敏感且无损伤监测指标。方法 研究饮水中加入不同浓度的Ｎａ２ＳｅＯ３（０，０．５，２．０，４．０ｍ ｇ／Ｌ）对同时加入的ＮａＦ（１５０ｍ ｇ／Ｌ）所致ＳＤ大鼠肾脏损害的影响，实验期７０ 天。结果 氟组大鼠血清ＬＰＯ 含量及７０ 天时肾组织ＬＰＯ含量显著升高，同时尿液中γ－ＧＴ、ＮＡＧ、ＡＫＰ在３５、５０ 和７０ 天时较对照组显著升高。饮水中２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 对ＮａＦ所致尿酶以及血清和肾组织ＬＰＯ 含量升高具有明显拮抗作用，４．０ｍ ｇ／ＬＮａ２ＳｅＯ３ 本身表现出一定的毒性作用。此外发现饮水中０．５ 和２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 可使大鼠８ 小时尿氟排泄量在７０ 天时显著上升（ Ｐ＜ ０．０５ 和Ｐ ＜ ０．０１）。结论 对于饮水中１５０ｍ ｇ／Ｌ ＮａＦ所致肾脏损害，２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 为最佳拮抗浓度。
Objective To find the optimal concentration of selenium to antagonize the action of flu and the sensitive and non-destructive monitoring index of fluorosis. Methods The effects of Na2SeO3 (0,0.5,2.0,4.0 m g / L) with different concentrations of Na2SeO3 in drinking water on the renal damage of SD rats induced by NaF (150 m g / L) 70 days. Results The level of serum LPO and the level of LPO in renal tissue increased significantly in the fluorosis group at the same time, while the levels of γ-GT, NAG and AKP in urine increased significantly at 35, 50 and 70 days. 2.0m g / L Na2SeO3 in drinking water could obviously antagonize NaF-induced urease and LPO in serum and kidney tissue, and 4.0m g / LNa2SeO3 itself showed some toxic effects. In addition, 0.5 and 2.0 m g / L Na2SeO3 in drinking water were found to significantly increase urinary fluoride excretion in rats at 70 days (P <0.05 and P <0.01). Conclusion For the renal damage caused by 150 m g / L NaF in drinking water, 2.0 m g / L Na2SeO3 is the best antagonistic concentration.