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将76例DPN患者随机分为单药组38例和联合组38例。在常规治疗基础上,单药组仅予以前列地尔10ug加入0.9%氯化钠注射液10ml中缓慢静注,1次/日,联合组在单药组治疗基础上加用单唾液酸四己糖神经节苷脂静脉滴注治疗,2组疗程均为2周。所有患者在试验前、后均接受临床神经症状、体征评估及肌电图检查。肌电图检测治疗前后正中神经、腓总神经的感觉传导速度(SNCV)及运动传导速度(MNCV)变化。结果联合组总有效率92.11%,高于单药组的78.95%;2组治疗后SNCV、MNCV较治疗前有明显改善,且联合组优于单药组,差异均有统计学意义(P<0.05)。2组均未见严重不良反应。结论前列地尔能有效治疗DPN,联合单唾液酸四己糖神经节苷脂应用疗效更佳,并且安全性良好。
Seventy-six patients with DPN were randomly divided into single drug group (38 cases) and combined group (38 cases). On the basis of routine treatment, the single drug group was given only 10ml of alprostadil plus 0.9% sodium chloride injection 10ml slow intravenous injection, 1 times / day, the combination group in the single drug group plus monosialin Glucose ganglioside intravenous infusion therapy, two groups of treatment were 2 weeks. All patients underwent clinical neurological symptoms, signs assessment and electromyography before and after the trial. The changes of sensory conduction velocity (SNCV) and motor conduction velocity (MNCV) of the median nerve and common peroneal nerve before and after EMG were measured. Results The total effective rate in the combined group was 92.11%, which was higher than that in the single drug group (78.95%). The SNCV and MNCV in the two groups were significantly improved compared with that before treatment, and the combined group was superior to the single drug group (P < 0.05). No serious adverse reactions were observed in both groups. Conclusions Alprostadil can effectively treat DPN. The combination of monosialotetrahexosyl ganglioside has better efficacy and safety.