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应用免疫组织化学LSAB方法，检测c－myc蛋白和增殖细胞核抗原（PCNA）在食管癌及癌旁中的表达。发现食管癌中PCNA、c－myc均有不同程度的表达。癌旁上皮PCNA几乎均为阳性而c－myc仅两例重度非典型增生上皮有少数细胞弱阳性。有淋巴结转移的食管癌组PCNA阳性率和c－myc蛋白表达均显著高于无转移组。c－myc蛋白和PCNA表达之间存在较好正变关系。c－myc基因激活和PCNA在食管癌变及癌转移中协同作用。
The expression of c-myc protein and proliferating cell nuclear antigen (PCNA) in esophageal cancer and paraneoplastic tissues was detected by immunohistochemical LSAB method. It was found that PCNA and c-myc have different degrees of expression in esophageal cancer. Paraneoplastic epithelium was almost all positive for PCNA and c-myc was only weakly positive for only two cases of severe dysplasia epithelium. The positive rates of PCNA and c-myc protein expression in esophageal cancer patients with lymph node metastasis were significantly higher than those without metastasis. There is a good positive relationship between c-myc protein and PCNA expression. C-myc gene activation and PCNA play a synergistic role in esophageal canceration and cancer metastasis.