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五十年代后期,恶性疟原虫对氯喹抗性首先出现在南美和印度支那次大陆,此后,逐渐波及疟疾呈地方性流行的大部分地区。因而磺胺多辛-乙胺嘧啶合剂、奎宁/四环素、甲氟喹、卤泛曲林以及最近的青蒿素类等成为替代药物。在东南亚、大洋洲西部至南美这一大片地区,磺胺多辛-乙胺嘧啶合剂已失去其原有的效用。泰柬和泰缅边境地区已产生多种药物抗性,青蒿素衍生物是最新起用的药物。药物压力的选择以及当地传播和流动人口带虫者是药物抗性动力学的关键因素。抗性的扩散取决于生态流行病学因素,其中移民与媒介参数起主要作用。严格按标准疗程服足药量井在监督下的合理服药,能够防止抗性的发生与扩散。
In the late 1950s, the resistance of Plasmodium falciparum to chloroquine first appeared in the subcontinent of South America and the Indochina, and since then it has gradually spread to most parts of endemic malaria. Thus, sulfadoxine-pyrimethamine combination, quinine / tetracycline, mefloquine, halofradrin and the recent artemisinin class become alternative drugs. In Southeast Asia, western Oceania to South America, a large area, sulfadoxine - pyrimethamine mixture has lost its original utility. The Thai-Cambrian and Thai-Myanmar border areas have produced multiple drug resistances and artemisinin derivatives are the latest drugs of their kind. The choice of drug stress, as well as local spread and migrant populations of insects, are key factors in drug resistance kinetics. The spread of resistance depends on ecological epidemiological factors, of which immigration and media parameters play a major role. In strict accordance with the standard course of treatment to take full dose of medicine under the supervision of reasonable medication, to prevent the occurrence and spread of resistance.