论文部分内容阅读
目的应用高胰岛素正葡萄糖钳夹技术评估我国成人隐匿性自身免疫性糖尿病(LADA)患者的胰岛素抵抗。方法研究对象分为LADA组、2型糖尿病(T2DM)组、正常对照(NC)组。糖尿病患者均为初诊未治,经2周胰岛素强化治疗血糖控制达标后进行研究。对全部研究对象空腹测定临床参数及生化指标,应用高胰岛素正葡萄糖钳夹技术测定胰岛素敏感性指数(ISI)。结果 LADA组FCP及FIns显著低于NC组(P<0.05),年龄、BMI、WHR、SBP、DBP、TC、TG、LDL-C、HDL-C与NC组比较,均无统计学差异。LADA组BMI、WHR、SBP、FIns、FC-P、TC、TG、LDL-C均显著低于T2DM组(P均<0.05)。NC组、LADA组、T2DM组ISI分别为12.83±1.09、6.70±0.71、3.80±0.20,三组间比较有统计学差异(P<0.05)。结论与NC组相比,LADA患者存在胰岛素抵抗,其程度较T2DM组轻。
Objective To evaluate the insulin resistance in patients with occult autoimmune diabetes (LADA) in our country by using hyperinsulinemic positive glucose clamp technique. Methods The subjects were divided into LADA group, type 2 diabetes mellitus (T2DM) group and normal control (NC) group. Diabetes patients were newly diagnosed, after 2 weeks of intensive insulin therapy to control blood glucose after the study. The clinical parameters and biochemical indexes of fasting test were determined in all the subjects. Insulin sensitivity index (ISI) was measured by using hyperinsulinemic positive glucose clamp technique. Results FCP and FIns in LADA group were significantly lower than those in NC group (P <0.05). There was no significant difference in age, BMI, WHR, SBP, DBP, TC, TG, LDL-C and HDL- The levels of BMI, WHR, SBP, FIns, FC-P, TC, TG and LDL-C in LADA group were significantly lower than those in T2DM group (all P <0.05). The ISI of NC group, LADA group and T2DM group were 12.83 ± 1.09,6.70 ± 0.71 and 3.80 ± 0.20 respectively, with statistical significance (P <0.05). Conclusion Compared with NC group, LADA patients have insulin resistance, which is lighter than T2DM group.