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采用反相细乳液聚合方法,以N-乙烯基己内酰胺(VCL)和甲基丙烯酸(MAA)单体为分散相,甲叉双丙烯酰胺(MBA)交联剂,氧化还原引发剂引发单体聚合,制得生物相容性好的纳米级多重响应性聚N-乙烯基己内酰胺甲基丙烯酸[P(VCL-MAA)]微凝胶。采用透射电镜(TEM)、激光粒径仪和红外光谱(FT-IR)方法对制备的微凝胶的形貌和结构进行了表征。结果表明,在45℃条件下用氧化还原引发剂的聚N-乙烯基己内酰胺(PVCL)及P(NVCL-MAA)微凝胶具有中空结构、球形均匀、粒径分布较窄的特征,有望在药物载体领域获得应用。
The reversed-phase miniemulsion polymerization method was used to polymerize monomers with N-vinylcaprolactam (VCL) and methacrylic acid (MAA) as disperse phase, methylene bisacrylamide (MBA) as crosslinking agent and redox initiator , To prepare biocompatible nano-scale multi-responsive poly N-vinyl caprolactam methacrylic acid [P (VCL-MAA)] microgels. The morphology and structure of the prepared microgels were characterized by transmission electron microscopy (TEM), laser particle size analyzer and Fourier transform infrared spectroscopy (FT-IR). The results show that the poly (N-vinylcaprolactam) (PVCL) and P (NVCL-MAA) microgels with redox initiator have the characteristics of hollow structure, uniform spherical shape and narrow particle size distribution at 45 ℃. Application of drug carrier field.