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[目的]观察CGA,Survivin蛋白在胃黏膜不同病理状态下的表达情况,探讨胃黏膜病理变化过程中的最佳外科癌前干预节点,并为胃癌生物靶向治疗寻找新的靶点.[方法]应用免疫组织化学方法检测CGA及Survivin蛋白在慢性浅表性胃炎、慢性萎缩性胃炎、胃黏膜不典型增生及胃癌组织中的表达,并进行相关性分析.[结果]胃黏膜不典型增生组CGA及Survivin蛋白表达明显高于慢性萎缩性胃炎组(P<0.05),胃癌组明显高于胃黏膜不典型增生组(P<0.05),且CGA表达与Surviviv表达呈正相关.[结论]胃黏膜不典型增生阶段是外科干预的最佳节点,Survivin有望成为胃癌生物靶向治疗的新的靶点.
[Objective] To observe the expression of CGA and Survivin in gastric mucosa under different pathological conditions and to explore the best surgical precancerous intervention node in the process of gastric mucosal pathological changes and to find a new target for the biologic targeted therapy of gastric cancer. ] Immunohistochemistry was used to detect the expression of CGA and Survivin protein in chronic superficial gastritis, chronic atrophic gastritis, gastric mucosa dysplasia and gastric cancer tissues, and to make correlation analysis. [Results] The gastric dysplasia group CGA and Survivin protein expression was significantly higher than that of chronic atrophic gastritis group (P <0.05), gastric cancer group was significantly higher than gastric dysplasia group (P <0.05), and CGA expression and Surviviv expression was positively correlated. [Conclusion] Gastric mucosa Surgical treatment of atypical hyperplasia stage is the best node, Survivin is expected to become a new target for the biological treatment of gastric cancer.