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目的:考察氟比洛芬巴布剂与对照混悬剂在人体内的药代动力学。方法:8名健康志愿者自身交叉口服混悬剂100mg或外贴巴布剂600mg,采用高效液相色谱（HPLC）法测定血浆中氟比洛芬浓度。结果:氟比洛芬混悬剂和巴布剂的t1/2分别为5.91和7.7h,MRT分别为5.93和19.4h,经单侧t检验均有显著差异（P<0.05）。结论:氟比洛芬巴布剂可以明显减少血药浓度波动,延长作用时间。
OBJECTIVE: To investigate the pharmacokinetics of flurbiprofen poultice and control suspensions in humans. Methods: Eight healthy volunteers were given 100mg of oral suspension or 600mg of external cataplasm, and the concentration of flurbiprofen in plasma was determined by HPLC. Results: The t1 / 2 of flurbiprofen suspension and cataplasm were 5.91 and 7.7 h, respectively. The MRTs were 5.93 and 19.4 h, respectively. Significant differences were observed by one-sided t test (P <0.05). Conclusion: Flurbiprofen pus preparation can significantly reduce the fluctuation of plasma concentration and prolong the action time.