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以往对高原世居者在低氧条件下红细胞生成的研究表明。喜玛拉雅山世居者(谢尔巴人)的红细胞压积及血红蛋白值比该高度上的预期值要低,这可能是由于遗传上的适应。然而,取样技术的实验方法上的不同使得比较变的困难。我们应用同样的实验技术比较了同一海拔高度,并且在年龄上匹配的喜玛拉雅山和安第斯山脉世居者的红细胞生成反应。健康男性选自:智利的Ollague,29人,平均年龄27.3±5.9岁;尼泊尔的Khunde,30人,平均年龄24.7±3.8岁,两地海拔高度均为3700米。血液学分析的结果发现,尼泊尔人的红细胞压积(48.4±4.5％较智利人(52.5±4.6％)低(P<0.003)。将受试者配对后分析红细胞压积发现,智利人红细胞生成素的浓度高于尼泊尔人(P<0.01)。对尼泊尔人的血氧亲和力的
Previous studies of erythropoiesis in high altitude natives under hypoxic conditions have shown. Hematocrit and hemoglobin values for Himalayas (Sherpa) are lower than expected at this height, probably due to genetic accommodation. However, differences in the experimental methods of sampling techniques make it more difficult. We used the same experimental technique to compare the erythropoietic responses of the same altitude and age-matched Himalayas and Andean settlers. Healthy men were selected from Ollague, Chile, 29 people, with an average age of 27.3 ± 5.9 years; Khunde, Nepal, 30 people, with an average age of 24.7 ± 3.8 years and 3700 meters above sea level. Hematology analysis showed that Nepalese hematocrit (48.4 ± 4.5%) was lower than that of Chilean (52.5 ± 4.6%) (P <0.003) .Based on the hematocrit analysis of paired patients, it was found that the cholestasis of Chilean Superoxide concentration was higher in Nepali (P <0.01)