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目的 :研究 3种不同给药方法在纤维电子胃镜中的镇静作用及对循环呼吸的影响。方法 :选择自愿接受无痛胃镜的患者90例 (按美国麻醉医师学会对术前病人的病情估计分级法ASAⅠ ～ Ⅱ级 ) ,随机分为 3组 :Ⅰ 组 (力蒙欣 2mg/kg) ,Ⅱ 组 (咪唑安定 0 .0 8mg/kg) ,Ⅲ 组 (力蒙欣 1 .3mg/kg+咪唑安定 0 .0 4mg/kg) ,每组各 30例。观察术中HR ,MAP ,SPO2 及镇静分级、苏醒时间、记忆缺失、呼吸抑制及自我感觉情况。结果 :Ⅰ 组MAP ,SPO2 下降 (注药后 1～ 3min)与 Ⅱ、Ⅲ两组比较差异有显著性 (P <0 .0 5) ;Ⅲ 组MAP(注药后 1～ 3min)虽有下降趋势 ,但与 Ⅱ 组比较差异无显著性 (P >0 .0 5)。镇静分级、苏醒时间、记忆缺失、呼吸抑制及自我感觉 Ⅰ、Ⅲ 两组组间无差异 ,但均明显优于 Ⅱ 组 (P <0 .0 5)。结论 :力蒙欣 1 .3mg/kg ,复合咪唑安定 0 .0 4mg/kg用于胃镜检查是安全有效的
OBJECTIVE: To study the sedative effects of three different administration methods in fibronectomy and their effects on circulatory respiration. Methods: Ninety patients who volunteered to be treated with painless gastroscope (ASAⅠ ~ Ⅱ grade according to the American Academy of Anesthesiologists’ preoperative evaluation) were randomly divided into three groups: group Ⅰ (2mg / kg) Group Ⅱ (midazolam 0.08 mg / kg), group Ⅲ (force Mengxin 1 .3mg / kg + midazolam 0. 04mg / kg), 30 cases in each group. The intraoperative HR, MAP, SPO2 and sedation classification, recovery time, memory loss, respiratory depression and self-feeling. Results: The decrease of MAP and SPO2 in group Ⅰ (1 ~ 3 min after injection) was significantly different from that of group Ⅱ and Ⅲ (P <0.05); the MAP in group Ⅲ (1 ~ 3 min after injection) Trend, but there was no significant difference between the two groups (P> 0.05). There was no difference between the two groups in sedation classification, recovery time, memory loss, respiratory depression and self-feeling, but both were significantly better than those in group Ⅱ (P <0.05). Conclusion: Simimeixin 1.3 mg / kg, combined with midazolam 0.04 mg / kg for gastroscopy is safe and effective