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目的探讨影响广西围产儿先天性心脏病发生的相关因素。方法采用成组病例对照的研究方法,对广西7个市1398例先天性心脏病围产儿和1398例正常围产儿的父母进行问卷调查,并对可能影响先天性心脏病发生的相关因素进行单因素及多因素Logistic回归分析。结果多因素Logistic回归分析结果显示:母亲怀孕前患病用药是先天性心脏病发生的危险因素(P<0.001,OR=40.5)。结论控制或减少父母双方工作生活环境中危险因素暴露,改善父母双方健康状况,加强孕期保健和宣教对于降低胎儿先天性心脏病发生风险尤为重要。
Objective To explore the influencing factors of congenital heart disease in Guangxi. Methods A case-control study was conducted to investigate the prevalence of 1398 cases of congenital heart disease and 1398 cases of normal perinatal children in 7 cities of Guangxi. The questionnaire was conducted to investigate the possible causes of congenital heart disease. And multivariate logistic regression analysis. Results The multivariate Logistic regression analysis showed that the mothers’ pre-pregnancy medication was a risk factor for congenital heart disease (P <0.001, OR = 40.5). Conclusions It is especially important to control or reduce exposure of risk factors in working and living environment of both parents, improve the health of both parents and strengthen the health and education during pregnancy to reduce the risk of fetal congenital heart disease.