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目的检测胰岛素样生长因子Ⅰ型受体(IGF-ⅠR)在肝细胞癌(HCC)、癌旁及正常肝组织中的表达,探讨HCC的发生机制。方法免疫组织化学染色SP法检测31例HCCIGF-ⅠR表达。结果正常肝组织胞膜、胞质均显淡黄色,分布均匀。在HCC中,IGF-ⅠR呈异常高表达90·3%(28/31),以膜及胞质混合型表达为主,其表达与肿瘤的大小、病理分级无显著性差异(P>0·05),在AFP、HBsAg、HCV抗原阴、阳性组间无显著性差异(P>0·05)。肝内多发结节或单发结节合并门脉癌栓的HCC,IGF-ⅠR高表达与单结节HCC组间有显著性差异(P<0·05)。HCC癌与癌旁组织均显著高于正常肝组织。结论IGF-ⅠR高表达可能与HCC的侵袭性行为有关。
Objective To detect the expression of insulin-like growth factor type I receptor (IGF-ⅠR) in hepatocellular carcinoma (HCC), adjacent normal tissues and normal liver tissues and to explore the mechanism of HCC. Methods Immunohistochemical SP method was used to detect the expression of HCCIGF-ⅠR in 31 cases. Results The normal liver tissue membrane, cytoplasm were light yellow, evenly distributed. In HCC, the expression of IGF-IR was abnormally high (90.3%, 28/31), with mixed expression of membrane and cytoplasm. The expression of IGF-IR was not significantly different from that of tumor size and pathological grade (P> 0. 05). There was no significant difference between negative and positive AFP, HBsAg and HCV antigens (P> 0.05). There was a significant difference between HCC and HCC in multiple intrahepatic or solitary nodules with portal vein tumor thrombus (P <0.05). HCC and paraneoplastic tissue were significantly higher than normal liver tissue. Conclusion The high expression of IGF-ⅠR may be related to the aggressive behavior of HCC.