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目的:了解成功行经皮冠状动脉介入治疗(PCI)病人的心肌肌钙蛋白T(cTnT)水平的动态改变及临床意义。 方法:选择成功行PCI术的68例患者,在术前、术后6 h、24 h分别检测肌酸激酶(CK)、肌酸激酶同功酶(CK- MB)及cTnT水平,并分析相关因素。结果:PCI术后CK-MB升高7例(10．3％)。cTnT术后升高32例(47．1％), C型病变:在cTnT升高组中17例(53．1％),与cTnT正常组10例(27．8％)比较有显著差异(P=0．033 0)。三 支血管病变:cTnT升高组中13例(40．6％),与cTnT正常组5例(13．9％)比较有显著差异(P=0．012 6)。cTnT 升高的原因和扩张压力总和、扩张次数及扩张时间有关(P=0．007 2．P=0．000 2,P=0．021 3),支架长度和支架 直径也和cTnT水平有关(P=0．015 6,P=0．001 2)。结论:PCI术后可引起CK-MB、cTnT水平轻度升高,在检 测心肌损伤方面cTnT较CK、CK-MB更敏感。病变的复杂程度及手术操作的强度与cTnT水平升高有关。
Objective: To investigate the dynamic changes and clinical significance of cardiac troponin T (cTnT) in patients undergoing percutaneous coronary intervention (PCI). Methods: Sixty-eight patients who underwent PCI were selected and the levels of creatine kinase (CK), creatine kinase MB (CK-MB) and cTnT were measured before operation, 6 h and 24 h after operation respectively factor. Results: CK-MB increased in 7 cases (10.3%) after PCI. There were 32 cases (47.1%) of patients with cTnT elevation after operation, C type: 17 cases (53.1%) in cTnT elevated group and 10 cases (27.8%) in cTnT normal group were significantly different P = 0.033 0). Three vessel lesions: 13 (40.6%) in the elevated cTnT group were significantly different from 5 (13.9%) in the normal cTnT group (P = 0.012 6). The causes of cTnT elevation were related to the sum of dilatation pressures, dilations and dilatation times (P = 0.007 2. P = 0.000 2, P = 0.021 3), and stent length and stent diameter were also related to cTnT levels P = 0.015 6, P = 0.001 2). Conclusions: The levels of CK-MB and cTnT may be slightly elevated after PCI. CTnT is more sensitive than CK and CK-MB in detecting myocardial injury. The complexity of the lesion and the intensity of the surgical procedure are related to elevated levels of cTnT.