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目的探讨早产儿颅内出血(intracranial hemorrhage,ICH)相关因素,为预防脑室周围-脑室内出血(periventricular-intraventricular hemorrhage,PIVH)、脑实质出血、蛛网膜下腔出血提供参考依据。方法选择2013年4月-2014年3月住院的确诊ICH的早产儿为病例组,同期住院非ICH早产儿为对照组,对相关因素进行回顾性研究。单因素分析用χ2检验,多因素分析用多元Logistic回归分析。结果 Logistic回归分析确定宫内窘迫、胎龄小于34周、机械通气、电解质紊乱为早产儿ICH独立危险因素,产前应用地塞米松是ICH的有利因素。结论加强对高危孕产妇孕期监测,及时发现和处理妊娠合并症,产前适时应用地塞米松等可减少早产儿ICH的发生。
Objective To investigate the related factors of intracranial hemorrhage (ICH) in preterm infants and provide a reference for prevention of periventricular-intraventricular hemorrhage (PIVH), cerebral parenchymal hemorrhage and subarachnoid hemorrhage. Methods Preterm infants diagnosed with ICH from April 2013 to March 2014 were selected as case group and non-ICH preterm infants as control group during the same period. The related factors were retrospectively studied. Univariate analysis using χ2 test, multivariate analysis using multiple logistic regression analysis. Results Logistic regression analysis confirmed that intrauterine distress, gestational age less than 34 weeks, mechanical ventilation, electrolyte imbalance was an independent risk factor for ICH in preterm infants, prenatal dexamethasone was a favorable factor for ICH. Conclusions The monitoring of high-risk pregnant women during pregnancy to strengthen the timely detection and treatment of pregnancy complications, timely prenatal application of dexamethasone can reduce the occurrence of ICH in preterm children.