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目的:分析不同年龄段女性乳腺癌患者临床病理特征。方法:收集在重庆市渝北区人民医院接受治疗并确诊为乳腺癌的120例患者的临床资料,进行回顾性分析。结果:青年组的乳腺癌患者在病理类型、淋巴结转移率、肿瘤大小、组织学分级、临床分期方面均与其他两组患者存在明显差异;人表皮生长因子受体2(HER-2)和孕激素受体(PR)阳性表达在各年龄比较,差异具有统计学意义(P<0.05)。雌激素受体(ER)的阳性表达率在各年龄段比较,差异均无统计学意义(P>0.05)。结论:年龄≤35岁的乳腺癌患者肿瘤恶性程度高于其他年龄段的患者,应需及时诊断并治疗,36~50岁是乳腺癌发病的高峰时期,中青年乳腺癌患者肿瘤侵袭性强,预后差,生物学行为较差;老年乳腺癌患者肿瘤生长缓慢,侵袭性弱,生物学行为较好。
Objective: To analyze the clinicopathological features of breast cancer patients of different ages. Methods: The clinical data of 120 patients who were treated and diagnosed as breast cancer in Yubei District People’s Hospital of Chongqing were collected for retrospective analysis. Results: There were significant differences between the two groups in the pathological type, lymph node metastasis rate, tumor size, histological grade and clinical stage in breast cancer patients. The expression of human epidermal growth factor receptor 2 (HER-2) and pregnancy The positive expression of hormone receptor (PR) in all age groups, the difference was statistically significant (P <0.05). The positive rate of estrogen receptor (ER) in all age groups, the difference was not statistically significant (P> 0.05). Conclusions: Patients with breast cancer ≤35 years of age have a higher degree of malignancy than other age groups and should be diagnosed and treated promptly. The peak age of breast cancer is 36 ~ 50 years old, Poor prognosis, poor biological behavior; elderly patients with breast cancer growth is slow, weak invasive, good biological behavior.