论文部分内容阅读
高分化鳞癌（ＷＤＳＣ）与假癌性增生（ＰＣＨ）的组织形态学鉴别迄今仍是外科病理学棘手难题之一。本文以抗人、抗牛角蛋白多克隆抗体，双ＰＡＰ法观察、分析其角蛋白抗原表达。结果表明：ＷＤＳＣ组２０例中１７例（８５％）呈不规则表型，２例基本阴性，仅１例规律型。ＰＣＨ组１０例中７例（７０％）呈规律性表型，３例呈弱杂乱不规则表型。两组角蛋白表型统计学处理差异显著（Ｐ＜０．０１）。本文认为仔细分析组织形态特征的同时，应用角蛋白抗体免疫组织化学观察对疑难的ＷＤＳＣ与ＰＣＨ的鉴别诊断有一定实际意义。
Histopathological differentiation of well-differentiated squamous cell carcinoma (WDSC) and pseudo- carcinoma hyperplasia (PCH) remains by far one of the thorny problems in surgical pathology. In this paper, anti-human, anti-keratin polyclonal antibody, dual PAP method observation, analysis of its keratin antigen expression. The results showed that: 17 cases (85%) of 20 cases in WDSC group showed irregular phenotype, 2 cases were negative and only 1 case was regular type. In 10 cases of PCH group, 7 cases (70%) showed regular phenotype and 3 cases showed weakly irregular irregular phenotype. Statistical difference between the two keratin phenotypes was significant (P <0.01). This paper argues that careful analysis of morphological characteristics of the tissue at the same time, the application of keratin antibody immunohistochemical observation of difficult WDSC and PCH differential diagnosis of some practical significance.