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目的:探讨化疗与手术对非小细胞肺癌患者的疗效及血清内皮抑素水平的影响。方法:选择2008-03/09我院收治的非小细胞肺癌患者92例,随机将患者分为治疗组和对照组,每组46例。治疗组采用长春地辛-异环磷酰胺-顺铂(VIP)方案化疗配合手术进行治疗,对照组则只单纯进行手术治疗。结果:与对照组相比,治疗组的完全缓解和有效比率显著升高,肿瘤进展的比率显著下降(P<0.05);而两组毒性反应的差异不显著。与对照组相比,治疗组患者血清内皮抑制素的含量明显升高(P<0.05)。结论:应用化疗与手术相结合的方法对非小细胞肺癌的治疗具有较好的效果,并能显著提高患者血清内皮抑制素的水平,增加机体免疫力,提高患者的生活质量。
Objective: To investigate the effects of chemotherapy and surgery on the efficacy of non-small cell lung cancer patients and serum endostatin levels. Methods: Ninety-two patients with non-small cell lung cancer admitted to our hospital from March 2008 to March 2008 were randomly divided into treatment group and control group, with 46 cases in each group. The treatment group was treated with vindesine-ifosfamide-cisplatin (VIP) regimen combined with surgery, while the control group was treated with surgery alone. Results: Compared with the control group, the complete remission and effective rate of the treatment group was significantly increased, the rate of tumor progression was significantly decreased (P <0.05), while the difference was not significant between the two groups. Compared with the control group, the serum endostatin level in the treatment group was significantly increased (P <0.05). Conclusion: The combination of chemotherapy and surgery has a good effect on the treatment of non-small cell lung cancer, and can significantly increase the level of serum endostatin in patients, increase body immunity, improve the quality of life of patients.