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为了解妊娠期间巨细胞病毒（ＣＭＶ）及单纯疱疹病毒（ＨＳＶ）感染及其特异性体液和细胞免疫状态，对１８３名妊娠妇女、２２名反复自发流产妇女和３２名非妊娠妇女进行病毒分离、抗体测定、病毒抗原特异性淋巴细胞增殖反应（ＬＰＲ）测定。早期和晚期妊娠妇女ＨＳＶ阳检率分别为２．７％（５／１８３）和１．０％（１／１０１），ＣＭＶ阳检率为１．１％（２／１８３）和２．０％（２／１０１）。妊娠妇女、反复自发流产妇女和非妊娠妇女ＣＭＶ抗体阳检率为５１．６％、５０％和３４．４％，ＨＳＶ抗体阳检率分别为８０．０％、８６．４％和７５％。近半数抗体阳性妊娠妇女ＣＭＶ－ＬＰＲ阴性；但对ＰＨＡ和ＨＳＶ抗原刺激反应良好，提示这些妊娠妇女存在ＣＭＶ特异性细胞免疫力低下。４名排出ＣＭＶ的妊娠妇女的ＣＭＶ－ＬＰＲ阴性，提示特异性细胞免疫力低下可能有利于潜伏ＣＭＶ感染的复活
To understand the cytomegalovirus (CMV) and herpes simplex virus (HSV) infections and their specific humoral and cellular immune status during pregnancy, 183 pregnant women, 22 spontaneous abortions and 32 nonpregnant women were subjected to virus isolation, Antibody assay, virus antigen-specific lymphoproliferative response (LPR) assay. The positive rates of HSV in early and late pregnant women were 2.7% (5/183) and 1.0% (1/101), respectively, and those with CMV were 1.1% (2/183) and 2.0% (2/101). The positive rates of CMV antibodies in pregnant women, recurrent spontaneous abortion women and non-pregnant women were 51.6%, 50% and 34.4% respectively. The positive rates of HSV antibodies were 80.0%, 86.4% and 75% respectively. Nearly half of antibody-positive pregnant women were negative for CMV-LPR; however, the response to PHA and HSV antigen stimulation was good, suggesting that these pregnant women had low CMV-specific cellular immunity. CMV-LPR negative in 4 pregnant women excreted with CMV suggests that low specific cellular immunity may be beneficial to the revival of latent CMV infection