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本研究为确定d,lα-生育酚对乳腺结构不良的治疗效果及生育酚治疗对病人的甾体内环境有何影响.d, lα-生育酚为维生素(Vit)E最活跃的生物学形式.作者对128例证实为乳腺结构不良的妇女进行随机双盲安慰-对照试验.病人每日用安慰剂或d,lα-生育酚150、300或600IU两个月;治疗前后于黄体中期做乳房检查,超声波显影或热显影.为除外恶性变,在本研究一年之内做乳腺造影.多数病人曾做过乳腺活检或穿刺.α-生育酚的浓度以Bieri等的方法测定,雌二醇、孕酮、硫酸脱氢表雄酮及睾丸酮的浓度用放射免疫方法测定.
This study was designed to determine the effect of d, lα-tocopherol on the treatment of breast dysplasia and the effect of tocopherol treatment on the patient’s steroid homeostasis.1d-tocopherol is the most active biological form of vitamin E. The authors randomized 128 double-blind, placebo-controlled, placebo-controlled, placebo-controlled or placebo-controlled 150,300 or 600 IU doses of maternal milk to women with proven mammographic dysfunction for two months; performed mid-luteal mammography before and after treatment , Ultrasound imaging or thermal imaging.In addition to malignant transformation, in this study within a year of breast imaging.Most patients had done breast biopsy or puncture.α-tocopherol concentration measured by the method of Bieri et al, estradiol, Progesterone, dehydroepiandrosterone sulfate and testosterone concentrations were measured by radioimmunoassay.