论文部分内容阅读
目的探讨肿瘤坏死因子（ＴＮＦ－α）和神经肽Ｐ物质（ＳＰ）在儿童哮喘发病中的作用。方法分别用放射免疫法和酶联免疫法检测２９例正常儿及５２例哮喘儿血浆ＳＰ和ＴＮＦ－α含量，同时测定５岁以上者气道反应性。结果哮喘发作期血浆ＳＰ含量明显增高（３６３±２１２ｐｍｏｌ／Ｌ，Ｐ＜０．０１），与气道反应性呈显著正相关（Ｐ＜０．０１），而ＴＮＦ－α在该阶段具保护作用，不能与ＳＰ协同升高；缓解期ＴＮＦ－α显著高于正常（１２７４±１４７３ｎｇ／Ｌ，Ｐ＜０．０１）。结论ＴＮＦ－α是气道炎症持续存在的重要原因。
Objective To investigate the role of tumor necrosis factor (TNF-α) and neuropeptide substance P (SP) in the pathogenesis of childhood asthma. Methods The levels of plasma SP and TNF-α in 29 normal children and 52 asthmatic children were detected by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. The airway responsiveness was measured at the same time of more than 5 years old. Results The content of SP in asthma attacked group was significantly increased (363 ± 212pmol / L, P <0.01), and was positively correlated with airway responsiveness (P <0.01), while TNF-α was protective in this stage , Not synergistically with SP; remission TNF-α was significantly higher than normal (1274 ± 1473ng / L, P <0.01). Conclusion TNF-α is an important cause of persistent airway inflammation.