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Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses.micro RNAs are differentially expressed according to the tissue of origin.However,there is rare research on the differential diagnosis between the two types of cancers by micro RNA in periampullary cancers.The present study was undertaken to compare micro RNA profiles between ampullary and pancreatic carcinomas using microarrays.mi R-215 was most significantly overexpressed in ampullary carcinomas;whereas the expressions of mi R-134 and mi R-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas.When these discriminatory micro RNAs were applied to liver metastases,they were correctly predicted for the tissue of origin.Although this study is limited by small sample size,striking difference in micro RNA expression and concordant expression of discriminating micro RNAs in primary tumors and metastases suggest that these novel discriminatory micro RNAs warrant future validation.
Distinguishing ampullary carcinoma from important carcinoma of pancreatic carcinoma is important because of their different prognoses. MicroRNAs are differentially expressed according to the tissue of origin. Despite, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. present the study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. Mi R-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of mi R-134 and mi R-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. These discriminatory microRNAs were applied to liver metastases, they were judged predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in micro RNA expression and concordant expression of discriminating micro RNAs in primary tumors and metastases suggest that these novel discriminatory micro RNAs warrant future validation.