论文部分内容阅读
长期以来认为乙肝疫苗对在宫内已被乙肝病毒感染的嬰儿是无效的?疚亩源死嘈律又忠呙缁蛄嫌τ肏BIG后,经长期随访发现虽然近期无效,但远期效果良好,表现在HBsAg阴转和抗-HBs产生。第一组疫苗组12例中HBsAg1岁时66.7%、2岁时83.2%转阴;而对照组为42.8%转阴,有的持续阳性到6岁以上。第二组为出生时HBsAg和/或HBeAg阳性并持续到6个月或更长者,疫苗组1岁时HBsAg虽仍阳性,但2岁时84.6%转阴;第三组出生时先用HBIG再用疫苗,HBsAg于6个月时81.3%、1岁时87.5%转阴,上述HBsAg阴转时多数出现抗-HBs。经长期随访说明乙肝疫苗对宫内感染乙肝病毒者仍有一定作用,联合应用HBIG效果可能更好。其机理尚待进一步研究,可能与新生儿期免疫反应特点有关。
Hepatitis B vaccine has long been considered ineffective for infants who have been infected with hepatitis B virus in the womb. After long-term follow-up, although long-term follow-up was found to be ineffective, The period effect is good, manifested in HBsAg negative and anti-HBs production. The first group of vaccine in 12 cases HBsAg 1 year old 66.7%, 2 years old 83.2% negative; while the control group was 42.8% negative, and some continued positive to 6 years of age. The second group was HBsAg and / or HBeAg positive at birth and lasted for 6 months or longer. In the vaccine group, HBsAg was still positive at 1 year of age, but 84.6% turned negative at 2 years. The third group was born with HBIG Re-use of the vaccine, HBsAg at 81.3% at 6 months, 87.5% at 1 year of negative, the majority of HBsAg negative anti-HBs appear anti-HBs. Long-term follow-up shows that hepatitis B vaccine still has some effect on intrauterine infection of hepatitis B virus, combined application of HBIG may be better. The mechanism remains to be further studied, may be related to the characteristics of immune response in the newborn period.