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目的:观察门冬氨酸鸟氨酸(LOLA)对肝癌合并肝硬化半肝切除术后肝功能的影响。方法:通过随机、对照的方法,将66例肝癌合并肝硬化行半肝切除患者分为2组,仅治疗组于术后1~7 d静脉应用LOLA。全部患者分别在术前及术后1、3、5、7、10、14 d抽外周静脉血检查谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TB)、直接胆红素(DB)。结果:治疗组术后1、3、5 d ALT明显低于对照组(P<0.05),术后3、5 d AST明显低于对照组(P<0.05)。治疗组术后7 d ALT恢复正常的比率高于对照组。LOLA对术后TB、DB无影响。两组术后肝功能不全的发生率无差异(P=0.557)。结论:LOLA能促进肝癌肝硬化半肝切除术后肝脏功能的早期恢复。
Objective: To observe the effect of ornithine ornithine (LOLA) on liver function in patients with hepatocellular carcinoma after partial hepatectomy. Methods: Sixty-six patients with hepatocellular carcinoma who underwent partial hepatectomy for liver cirrhosis were divided into two groups by randomized and controlled methods. Only LOLA was intravenously administered in the treatment group from 1 to 7 days after operation. Peripheral venous blood was collected for ALT, AST, TB, and immediate bile flushing in all patients before and 1, 3, 5, 7, Prime (DB). Results: The ALT of the treated group was significantly lower than that of the control group on the 1st, 3rd and 5th postoperative days (P <0.05). The AST on the 3rd and 5th postoperative day was significantly lower than that of the control group (P <0.05). The ALT recovery rate in the treatment group 7 d after operation was higher than that in the control group. LOLA had no effect on postoperative TB and DB. There was no difference in the incidence of postoperative liver dysfunction between the two groups (P = 0.557). Conclusion: LOLA can promote the early recovery of liver function in patients with liver cancer after partial hepatectomy.