大剂量马利兰治疗慢粒伴阴茎持续勃起一例

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慢性粒细胞白血病(以下简称慢粒)伴有阴茎持续勃起,曾被认为是本病的特征表现之一,但临床少见。近年来,国内陆续报道数例,而治疗较为棘手。我院一例试用大剂量马利兰持续治疗使其缓解,现报告如下: 患儿,男性,12岁,住院号860092。因右小腿外伤不愈,头昏,乏力2周,于1986年1月住我院内科。体检:T36℃,发育、营养较差,贫血貌,皮肤粘膜无瘀点、瘀斑。两侧颈部及腹股沟触及数个黄豆大小质中稍活动之淋巴结。心肺正常。肝肋下7cm,剑突下5cm,硬度Ⅲ°。脾下缘达脐下3cm,硬度量Ⅲ°。无移动性浊音。泌尿生殖系及神经系统均无异常发现。右小腿见3×3cm糜烂面,有少量渗液。实验室检查:白细胞800×10~9/L,幼稚细胞占8%,以中晚幼粒 Chronic myeloid leukemia (hereinafter referred to as CML) with penile persistent erection, has been considered as one of the characteristics of the disease, but clinically rare. In recent years, several cases have been reported in China, and the treatment is more difficult. In our hospital a trial of large doses of malitis continued treatment to alleviate it, are as follows: children, men, 12 years old, hospital number 860092. Due to traumatic right calf injury, dizziness, fatigue for 2 weeks, in January 1986 to live in our hospital. Physical examination: T36 ℃, development, poor nutrition, anemia appearance, skin and mucous membrane petechiae, ecchymosis. Both sides of the neck and groin touched several soybean size slightly active in the lymph nodes. Cardiopulmonary normal. Liver ribs 7cm, xiphoid 5cm, hardness Ⅲ °. Under the edge of the spleen up to 3cm umbilical, hardness amount Ⅲ °. No shifting dullness. Genitourinary and nervous system were no abnormal findings. Right leg see 3 × 3cm erosion surface, a small amount of exudate. Laboratory tests: white blood cells 800 × 10 ~ 9 / L, naive cells accounted for 8% of young and middle-aged
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