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轮状病毒是引起婴幼儿腹泻的重要病原体,该病毒颗粒的VP4在病毒颗粒吸附和侵入宿主细胞过程中发挥着重要作用。最近研究发现VP4刺突蛋白远端的VP8*与人类组织血型抗原结合,是轮状病毒新的受体,并发表在Nature,Journal of Virology等杂志。本文对人类组织血型抗原与轮状病毒之间的研究进展进行简要概述,总结已有的研究结果,阐明组织血型抗原与轮状病毒研究的重要意义。
Rotavirus is an important causative agent of diarrhea in infants and young children. VP4 of this virus particle plays an important role in the adsorption and invasion of virus particles into host cells. Recent studies have found that VP8 * distal to VP4 spike protein binds to human tissue type antigens and is a new receptor for rotavirus and has been published in Nature, Journal of Virology and others. This article briefly summarizes the research progress between human blood group antigen and rotavirus, summarizes the existing research results and clarifies the significance of tissue blood group antigen and rotavirus research.