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运用聚合酶链反应及单链构型多态性技术分析５２例Ⅱ型糖尿病（ＮＩＤＤＭ）者及５４例正常对照组胰岛素受体基因第１７及２０外显子的变异。结果显示：外显子１７的１００８位ＧＧＣ－ＧＧＴ多态性频率在ＮＩＤＤＭ组为２９．４％，而在正常对照组为９．０７％（χ２＝１０．０２，Ｐ＜０．００５）。外显子２０的１１６９位甘氨酸多态性ＧＧＴ→ＧＧＣ在ＮＩＤＤＭ与正常对照组的频率分别为１５．４％和３．７％（χ２＝４．３７０，Ｐ＜０．０５）。上述结果显示：１００８位及１１６９位多态性可能是中国人群ＮＩＤＤＭ的发病危险因素
The variations of exon 17 and exon 17 of insulin receptor gene in 52 cases with type 2 diabetes mellitus (NIDDM) and 54 normal controls were analyzed by polymerase chain reaction and single strand conformation polymorphism. The results showed that the GGC-GGT polymorphism at exon 17 was 29.4% in the NIDDM group and 9.07% in the normal control group (χ2 = 10.02, P <0.005). The 1169 glycine polymorphism GGT → GGC in exon 20 was 15.4% and 3.7% respectively in NIDDM and normal controls (χ2 = 4.370, P <0.05). The above results show that: 1008 and 1169 polymorphisms may be the risk factors of NIDDM in Chinese population