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用Dowex50树脂吸附90Sr-90Y平衡体制成90Y发生器，用柠檬酸钠缓冲液淋洗得到90Y。在pH≥8．0时，90Y与Bio－Rex70树脂结合4h，结合率达90％以上。90Y标记树脂经动脉导管选择性地注入狗的右下肝叶，给药后4h内血中90Y的总量约为给药总剂量的1％。两周后X－CT成像显示，给药肝叶呈液化性坏死，大体标本观察见给药肝叶萎缩，病理检查见肝细胞成片死亡。结果表明，90Y标记树脂是一种有效、安全的放射杀伤制剂，结合选择性动脉导管给药，可以试用于肿瘤病灶的放射治疗。
The 90Y generator was prepared by adsorbing the 90Sr-90Y equilibrated body with Dowex 50 resin and eluted with sodium citrate buffer to obtain 90Y. At pH ≥ 8.0, 90Y and Bio-Rex70 resin combined for 4 h, the binding rate of more than 90%. The 90Y-labeled resin was selectively injected into the right lower lobe of the dog via the arterial catheter. The total amount of 90Y in the blood within 4 hours after administration was about 1% of the total dose administered. Two weeks later, X-CT imaging showed liquefaction necrosis of the administered hepatic lobe. The gross specimens were observed for hepatic lobe atrophy. Histopathological examination revealed death of hepatocytes. The results showed that the 90Y-labeled resin is an effective and safe radiation killing agent, combined with selective arterial catheterization, can be applied to radiotherapy of tumor lesions.