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目的分析38例急性有机锡中毒性脑病的临床表现及血钾变化,以便更好地进行诊断和诊疗工作。方法采用回顾性方法对38例急性有机锡中毒性脑病患者的临床表现及血钾变化情况,进行总结,分析临床特点,比较治疗前后血钾变化及低血钾程度与中毒轻重的关系。结果 38例急性有机锡中毒性脑病患者临床表现中腱反射减弱者、头晕头痛者及睡眠障碍者较常见,分别占92.11%、89.47%及71.45%;治疗前38例患者血钾平均(2.87±0.41)mmol/L,治疗10 d后血钾水平明显升高,平均(3.92±0.63)mmol/L,差异有统计学意义(t=8.61,P<0.01)。且低血钾程度与中毒轻重呈正相关(r=0.026,P<0.05)。结论急性有机锡中毒性脑病患者临床常有腱反射减弱、头晕头痛及睡眠障碍等表现,血钾水平可作为病情判断及治疗评价的指标。
Objective To analyze the clinical manifestations and changes of serum potassium in 38 cases of acute organotin toxic encephalopathy in order to make better diagnosis and treatment. Methods A retrospective analysis of 38 patients with acute organotin poisoning encephalopathy in patients with clinical manifestations and changes in serum potassium were summarized and analyzed the clinical characteristics of the changes in serum potassium levels before and after treatment and the relationship between hypokalemia and the severity of poisoning. Results Thirty-eight patients with acute organotin poisoning encephalopathy were found to be more common in those with weakened tendon reflexes, dizziness, headache and sleep disorders, accounting for 92.11%, 89.47% and 71.45% respectively. The average serum potassium level of 38 patients before treatment was 2.87 ± 0.41) mmol / L, and the serum potassium levels increased significantly after treatment for 10 days (mean, 3.92 ± 0.63 mmol / L). The difference was statistically significant (t = 8.61, P <0.01). The level of hypokalemia was positively correlated with the severity of poisoning (r = 0.026, P <0.05). Conclusion Patients with acute organotin poisoning encephalopathy usually have weakened tendon reflexes, dizziness, headache and sleep disorders, and serum potassium level can be used as an indicator of disease judgment and treatment evaluation.