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[目的]观察壬菌铜原药对大鼠的毒性作用和无作用剂量。[方法]将壬菌铜原药按0、2.5、25、250 mg/kg剂量分别拌入饲料内经口喂饲染毒90 d,观察大鼠外观体征、体质量、进食情况等。染毒结束进行血常规、血生化、脏器系数及病理组织学检测。[结果]高剂量组雌、雄性大鼠的体质量增长显著低于对照组。摄食受到抑制,血常规、血生化、尿液检查均未出现明显异常的指标改变。[结论]确定大鼠90 d亚慢性经口最大无作用剂量为2.5 mg/kg,推荐ADI值为0.002 5 mg/kg。
[Objective] To observe the toxic effect and non-action dose of the original strain of Renzhu copper in rats. [Method] The non-bacteria copper raw drugs were respectively mixed into the feed at doses of 0, 2.5, 25 and 250 mg / kg for 90 days to observe the appearance signs, body weight, food intake and so on. End of the treatment of blood, blood biochemistry, organ coefficient and pathological examination. [Result] The body weight of female and male rats in high dose group was significantly lower than that in control group. Ingestion was inhibited, blood tests, blood biochemistry, urine tests showed no significant abnormal changes in indicators. [Conclusion] The maximal non-acting dose of subchronic oral administration at 90 d was 2.5 mg / kg. The recommended ADI was 0.002 5 mg / kg.