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目的探讨在动脉粥样硬化性脑梗塞（ＡＣＩ）发生中血管紧张素转换酶（ＡＣＥ）基因与血管紧张素Ⅱ受体１型（ＡＴ１Ｒ）基因多态性的关系。方法采用聚合酶链反应－限制性片段长度多态性技术分别检测８１例ＡＣＩ患者和１０２例健康对照的ＡＣＥ和ＡＴ１Ｒ基因型。结果ＡＣＥ基因ＤＤ型与ＡＣＩ的发生显著相关（Ｐ＜０．０５）。在携带有ＡＣＥ基因ＤＤ型的群体中，ＡＴ１Ｒ基因型ＡＡ的个体患ＡＣＩ的比数比为１．３９，ＡＴ１Ｒ基因型ＡＣ患ＡＣＩ的比数比为３．６６，ＡＴ１Ｒ基因型ＣＣ患ＡＣＩ的比数比为５．８４。结论在ＡＣＩ发生中ＡＣＥ基因和ＡＴ１Ｒ基因多态性具有协同作用。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene and angiotensin Ⅱ receptor type 1 (AT1R) gene polymorphism in the development of atherosclerotic cerebral infarction (ACI). Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect the ACE and AT1R genotypes in 81 ACI patients and 102 healthy controls respectively. Results ACE gene DD type was significantly associated with the occurrence of ACI (P <0.05). In populations carrying the ACE gene DD type, the odds ratio for individuals with AT1R genotype AA with ACI was 1.39, the odds ratio for AT1R genotype AC with ACI was 3.66, the ACI with AT1R genotype CC with ACI The odds ratio is 5.84. Conclusion There is a synergistic effect between ACE gene and AT1R gene polymorphism in ACI.