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Biswanger病的症状之一为痴呆,其组织学特征为多发性腔隙梗塞和弥漫性非空洞性白质变性,在CT表现为弥漫性低密度影,在MRI T_2加权则表现为高信号区,这就构成了Biswanger病的诊断。然而,并非有上述改变的病人均表现为痴呆。实际上,决定这些弥漫性白质病变病人智能的因素仍不十分清楚。目前认为胼胝体萎缩可能导致轴索的破坏,且萎缩的程度可能和认知障碍有关。笔者用MRI定量分析腔隙梗塞和弥漫性白质变性病人的胼胝体萎缩,并且测定了萎缩程度和智能改变的关系,探讨了
One of the symptoms of Biswanger’s disease is dementia with histologic features of multiple lacunar infarcts and diffuse non-vacuolated white matter degeneration, diffuse low-density images at CT, and high signal areas at MRI T-2 weighting It constitutes a diagnosis of Biswanger’s disease. However, patients who did not make the above changes showed dementia. In fact, the factors that determine the intelligence of these patients with diffuse white matter disease are still not well understood. Now that the corpus callosum atrophy may lead to axonal damage, and the degree of atrophy may be related to cognitive disorders. The author uses MRI to quantitatively analyze the corpus callosum atrophy in patients with lacunar infarction and diffuse white matter degeneration and to determine the relationship between the degree of atrophy and the changes in intelligence.