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环孢霉素是一种T淋巴细胞活性的抑制剂,也是目前用于器官移植的最重要的免疫抑制药物,其治疗剂量无严重的肝损害.本文通过动物实验,研究了环孢霉素对肝细胞再生的影响.实验先将25只狗做成埃克瘘(Eck fistula)模型,即行门-腔静脉侧-侧吻合,于其上方结扎门静脉及其左、右支,然后于门静脉左支置一插管接于泵上,进行持续4天的灌注.环孢霉素的灌注剂量分别为0.06、0.6和4.0mg/kg/天;对照组分两组:一组是以与实验组相同的比率灌注环孢霉素的载体,即生理盐水中的非离子表面活化剂及乙醛,另一组是以胰岛素0.42u/kg进行灌注.每天取周围静脉血测定血药浓度及肝、肾功能的指标;4天后,每只动物予
Cyclosporine, an inhibitor of T lymphocyte activity, is also the most important immunosuppressive drug currently used in organ transplantation, and its therapeutic dose is no serious liver damage.In this paper, we studied the effect of cyclosporin Hepatocyte regeneration.We first made 25 dogs into the model of Eck fistula, which is the line - side vena cava anastomosis, the portal vein and its left and right branches were ligated above it, then the left branch of the portal vein A cannula was connected to the pump and perfusion was continued for 4 days.The doses of cyclosporine were 0.06, 0.6 and 4.0 mg / kg / day, respectively; two control groups: one group was the same as the experimental group Of the perfusion of cyclosporine carrier, namely non-ionic surfactant in normal saline and acetaldehyde, and the other group is perfusion with insulin 0.42u / kg. Peripheral blood taken from the blood concentration and liver and kidney Functional indicators; 4 days after each animal given