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目的通过检测卵巢上皮性恶性肿瘤组织中干细胞因子SOX2的表达水平,了解其表达与卵巢上皮性恶性肿瘤病理特征之间的关系。方法采用免疫组化法检测98例卵巢上皮性恶性肿瘤患者术后癌组织标本中SOX2蛋白的表达水平,探讨其与卵巢上皮性恶性肿瘤临床病理特征及发生发展关系。结果卵巢上皮性恶性肿瘤组织、良性肿瘤组织中SOX2阳性表达率分别为79.6%,35.0%,在正常卵巢组织中无表达。其表达水平与卵巢上皮性恶性肿瘤的分化程度、有无淋巴结转移有关,而与年龄、组织类型无关。结论 SOX2在卵巢上皮性恶性肿瘤中高表达,可能预示该肿瘤侵袭性高、预后差、易复发。
Objective To detect the expression of SOX2 in ovarian epithelial malignant tumor tissues and to investigate the relationship between the expression of SOX2 and the pathological features of ovarian epithelial malignant tumor. Methods Immunohistochemical method was used to detect the expression of SOX2 protein in 98 cases of epithelial ovarian cancer after operation. The relationship between the expression of SOX2 protein and the clinicopathological features and occurrence and development of ovarian epithelial malignant tumor was analyzed. Results The positive expression rates of SOX2 in epithelial ovarian cancer tissues and benign tumor tissues were 79.6% and 35.0% respectively, which were not expressed in normal ovarian tissues. The expression level of ovarian epithelial malignant tumor differentiation, with or without lymph node metastasis, but with age, type of tissue has nothing to do. Conclusion SOX2 is overexpressed in epithelial ovarian cancer, which may indicate that the tumor is highly aggressive and has poor prognosis and relapse.