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介入性肾脏交感神经消融术(renal sympathetic denervation,RD)可降低难治性高血压患者静息时的血压。该研究旨在探讨RD后心肺系统对运动反应的影响。方法 :入选了46例难治性高血压患者进行研究,作为“难治性高血压患者肾交感神经消融术临床试验”(Symplicity HTN-2)的延伸调查。将患者分为RD组(行双侧RD,n=37)和对照组(n=9)。在术前和术后3月随访时进行心肺运动试验。结果 :与术前检查时比较,3月后RD组患者静息时和运动量达最大时的血压明显降低[收缩压(31±13)/舒张压
Interventional renal sympathetic denervation (RD) reduces the resting blood pressure in patients with refractory hypertension. The aim of this study was to investigate the effect of cardiopulmonary system on motor response after RD. METHODS: Forty-six patients with refractory hypertension were enrolled as an extension of the “Symplicity HTN-2” trial of patients with refractory hypertension. Patients were divided into RD group (bilateral RD, n = 37) and control group (n = 9). Cardiopulmonary exercise tests were performed preoperatively and at 3 months after surgery. Results: Compared with the preoperative examination, the blood pressure of RD group was significantly lower at rest and at maximum exercise after 3 months [systolic blood pressure (31 ± 13) / diastolic blood pressure