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目的了解杭州市健康人群中麻疹抗体水平,为制定消除麻疹策略提供科学依据。方法1991-2007年在不同区(县、市)分2～4,6～8,13～15和25～39岁四个年龄组开展,采用血凝抑制试验对3985名健康人群检测麻疹血凝抑制抗体。结果农村总阳性率为87.25%,城市阳性率为92.11%,保护率差异有统计学意义(χ2=27.71,P<0.01);四个年龄组间阳性率差异有统计学意义(χ2=45.05,P<0.01),四个年龄组间的GMT值差异有统计学意义(F=30.73,P<0.01),阳性率和GMT值均以2～4岁组与6～8岁组为高。结论及时掌握人群的免疫水平,进一步提高麻疹疫苗的常规接种率和加强大年龄组人群麻疹疫情的监测是消除麻疹关键所在。
Objective To understand the level of measles antibody in healthy population in Hangzhou and provide a scientific basis for formulating measles elimination strategy. Methods 1991-2007 in different districts (counties, cities) in 2-4 age groups, 6 ~ 8, 13 ~ 15 and 25 to 39 years of age to carry out the use of hemagglutination inhibition test on 3985 healthy people measles blood coagulation Antibodies. Results The total positive rate in rural areas was 87.25%, the positive rate in urban areas was 92.11%, and the difference in protective rates was statistically significant (χ2 = 27.71, P <0.01). There was significant difference in the positive rates among the four age groups (χ2 = 45.05, P <0.01). There was a significant difference in GMT between the four age groups (F = 30.73, P <0.01). The positive rates and GMT values were higher in the groups of 2 to 4 years and 6 to 8 years. Conclusions It is the key to eliminating measles because it is timely to grasp the immunization level of the population, to further improve the routine vaccination rate of measles vaccine and to strengthen the measles epidemic situation in the large age group.