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应用SP免疫组织化学染色方法检测 60例胃癌和 2 0例癌前病变中C erbB 2 ,P53和P2 1基因的过度表达 ,多基因阳性在胃癌中为 35 % ,癌前病变中为 0 % ,多基因表达明显提示胃癌预后差。C erbB 2 ,P53和P2 1的多基因表达的检测对胃癌的预后判断明显优于其中某个单基因表达的检测。
Immunohistochemical SP immunohistochemistry was used to detect the overexpression of C erbB 2 , P53 and P2 1 genes in 60 cases of gastric cancer and 20 cases of precancerous lesions. The positive rate of multiple genes was 35% in gastric cancer and 0% in precancerous lesions. Multiple gene expression clearly suggests poor prognosis of gastric cancer. The detection of multiple gene expressions of C erbB 2 , P53 and P21 is significantly superior to the detection of single gene expression in the prognosis of gastric cancer.