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自从1967年Butrer等首先制造出了地戈辛抗体以来,多数医生认为利用放射免疫方法测定地戈辛血清浓度能够更安全和更有效的指导使用洋地黄甙。由于人们已注意到洋地黄中毒的一些情况,处理方法也得到改进,洋地黄中毒率正在下降。“抗体”本身意味着治疗洋地黄中毒的潜力。当然,尚有许多问题待于解决。有必要弄清药物—抗体复合物的变性和排泄机制,证明在人类应用是安全和有效的。近年来,用地戈辛抗体治疗散发的洋地黄中毒病例获得成功。
Since 1967 when Butler et al. First produced Gooxin antibodies, most physicians consider the use of radiosurgery to determine Degoxin serum levels may be safer and more effective in guiding use of digitalis glycosides. As people have noticed some cases of digitalis poisoning, treatment has also been improved, the rate of digitalis poisoning is declining. “Antibodies” by themselves mean the potential of treating digitalis intoxication. Of course, there are still many problems to be solved. It is necessary to clarify the mechanisms of degeneration and excretion of drug-antibody complexes, proving that they are safe and effective for human use. In recent years, the use of antibodies to geoxim distributed digitalis poisoning cases were successful.