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百口咳菌苗含有生物学活性的淋巴细胞增多促进因子(LPF)和内毒素,人体内毒素可引起嗜中性白细胞增多。在百日咳患者中具有生物学活性的LPF可导致淋巴细胞增多的白细胞增多。本世纪初,用粗制的百日咳菌苗对儿童进行超免疫,结果产生了淋巴细胞增多的白细胞增多。此外,给小鼠接种大剂量的百日咳菌苗,结果引起大量的淋巴细胞增多的白细胞增多。
Hundred cockroach vaccine contains a biological activity of lymphocyte proliferation promoting factor (LPF) and endotoxin, human toxins can cause neutrophilia. The biologically active LPF in patients with pertussis causes lymphocytosis with leukocytosis. At the beginning of this century, children were hyperimmunized with a crude pertussis vaccine and the result was an increase in leukocytosis with lymphocytosis. In addition, vaccination of mice with large doses of pertussis vaccine resulted in a large number of leukocytosis with lymphocytosis.